Hepatitis B vaccine (newborn)

The first dose of the hepatitis B series, often given in the hospital.

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What is it

A vaccine that begins protection against hepatitis B virus, which can cause chronic liver disease.

How your body works here

Hepatitis B is transmitted through blood and body fluids. If a birthing person is HepB-positive (sometimes without knowing), transmission at birth leads to chronic infection in ~90% of exposed babies, dramatically raising their lifetime risk of liver cancer and cirrhosis. The birth-dose vaccine primes the newborn's immune system to make antibodies before the virus can establish itself, which is why the timing at birth — not just eventually — matters most for babies born to positive or unknown-status parents.

Benefits (B)
Risks (R)
Alternatives (A)
  • Delay the first dose until the pediatrician's office if maternal hepatitis B status is negative and baby is otherwise healthy (discuss with your team).Review sources ↓
Run BRAIN with Labor LensGet Benefits, Risks, Alternatives, Intuition, and Nothing/Wait for Hepatitis B vaccine (newborn) — plus questions for your care team.
Evidence summary

Recommended at birth by the AAP and CDC. Required at birth in some clinical situations.

Sources
Questions to ask your provider
  • What's the recommendation given my status?
  • If I'd like to delay, when would the first dose be given?
Intuition & Nothing/Wait (the I and N in BRAIN)

What is your gut telling you? What happens if you do nothing or wait?

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