What it is
Preeclampsia is thought to start with problems in how the placenta connects to the uterus, leading to widespread blood-vessel changes. It is diagnosed when new high blood pressure appears after 20 weeks along with either protein in the urine (proteinuria) or signs that organs (liver, kidneys, platelets, brain) are being affected. Symptoms can include severe headache, vision changes, upper-belly pain, sudden swelling, or decreased fetal movement — but many people have no symptoms, which is why blood pressure and urine are checked at every prenatal visit. The only cure is birth of the baby and placenta; timing balances the parent's health with the baby's maturity.
Evidence review links
Each link opens the full review on the publisher's site in a new tab.
- ACOG Practice Bulletin 222: Gestational Hypertension and PreeclampsiaACOG
- ACOG Committee Opinion 743: Low-Dose Aspirin Use for the Prevention of Preeclampsia and Related Morbidity and MortalityACOG
- WHO recommendations on prevention and treatment of pre-eclampsia and eclampsiaWHO
- Preeclampsia and Long-Term Cardiovascular Risk (Scientific Statement)American Heart Association
Possible benefits
- Routine blood pressure and urine checks catch most cases before they become severe[ACOG↗][WHO↗]
- Low-dose aspirin starting between 12–28 weeks lowers the risk in people at higher risk[ACOG↗]
- Magnesium sulfate in labor reduces the chance of seizures (eclampsia) in severe cases[ACOG↗]
- Delivery cures preeclampsia; risks to the birthing person drop quickly after birth[ACOG↗]
Possible risks
- Can progress to severe preeclampsia, HELLP syndrome, seizures, stroke, or placental abruption if not managed[ACOG↗]
- Often leads to induction or cesarean before 40 weeks, sometimes preterm[ACOG↗]
- Magnesium sulfate is effective but uncomfortable (flushing, heaviness, slowed reflexes)[ACOG↗]
- Raises long-term risk of high blood pressure, heart disease, and stroke — postpartum follow-up matters[ACOG↗][American Heart Association↗]
Alternatives
- Close monitoring (blood pressure checks, labs, ultrasounds) instead of immediate delivery when preeclampsia is mild and baby is preterm[ACOG↗]
- Blood pressure medications (labetalol, nifedipine, methyldopa) to control pressure while pregnancy continues[ACOG↗]
- Home blood-pressure monitoring between visits if your provider agrees[ACOG↗]
- There is no proven prevention that replaces low-dose aspirin for people at increased risk[ACOG↗]
Current evidence
ACOG Practice Bulletin 222 defines preeclampsia (with and without severe features) and lays out expectant vs. delivery management by gestational age. ACOG Committee Opinion 743 covers low-dose aspirin for prevention. The WHO recommends calcium supplementation in low-calcium populations. Postpartum preeclampsia can appear up to 6 weeks after birth, so warning signs should be watched for at home.
Where the evidence is clear · where people may choose differently
For most topics, guidelines from ACOG, WHO, and other major bodies broadly agree on the core safety points (when to act in an emergency, informed-consent standards, monitoring baselines). Where reasonable people — and even guidelines — differ tends to be around thresholds (when to start or stop something), preferences (comfort, environment, support), and values (how you weigh small risks against benefits). Use the questions below to explore those pieces with your care team.
Educational only. Your care team can help you weigh what applies to your specific situation.
Related evidence topics
Questions to ask your care team
- ?What is my baseline blood pressure, and what number would concern you?
- ?Am I high enough risk to start low-dose aspirin, and if so, when?
- ?What warning signs should send me in right away — before my next visit?
- ?If I develop preeclampsia, how will you decide between waiting and delivering?
- ?What postpartum follow-up will I need for my blood pressure?
Universal questions (works for any decision)
A short BRAIN-style set you can bring to any conversation about interventions, monitoring, or care decisions.
- ?Why are you recommending this now — is it urgent, routine, or optional?
- ?What happens if we wait an hour (or longer) before deciding?
- ?What signs would tell us this is working — or that we need to change course?
- ?What are the alternatives, including doing nothing?
- ?What would you recommend if this were your family?
- ?What would change your recommendation?
Sources & provenance
Tap a source to open the original guideline or review in a new tab.
- ACOG Practice Bulletin 222: Gestational Hypertension and Preeclampsia — ACOG
- ACOG Committee Opinion 743: Low-Dose Aspirin Use for the Prevention of Preeclampsia and Related Morbidity and Mortality — ACOG
- WHO recommendations on prevention and treatment of pre-eclampsia and eclampsia — WHO
- Preeclampsia and Long-Term Cardiovascular Risk (Scientific Statement) — American Heart Association
Written in plain language from general guidance published by the listed organizations. No verbatim excerpts; editors should re-verify thresholds and criteria against the current source versions before publish.
Last reviewed: 2026-07-03
Further reading — canonical references
Read the source material directly. Each link opens the publisher's own current guidance in a new tab — cross-check what we summarize against what they say.
Tier 1 · Clinical guidelines
- ACOG guidance on “Preeclampsia (High Blood Pressure + Protein in Urine)”ACOG — U.S. clinical guidelines from the American College of Obstetricians and Gynecologists.
- NICE guidance on “Preeclampsia (High Blood Pressure + Protein in Urine)”NICE — UK clinical guidelines — often useful when ACOG and WHO differ.
Tier 2 · Systematic reviews
- Cochrane reviews on “Preeclampsia (High Blood Pressure + Protein in Urine)”Cochrane Library — Systematic reviews — top of the evidence stack when available.
- PubMed studies on “Preeclampsia (High Blood Pressure + Protein in Urine)”PubMed — Primary research — filter by review or meta-analysis for strongest evidence.
Educational only. Guidelines evolve — the linked publisher pages will reflect newer guidance than any static snapshot.
Version history — v1.0.0
v1.0.0 · 2026-07-03 · LlaMamma editors
Initial preeclampsia topic added with ACOG, WHO, and AHA references.
New guidance from ACOG, WHO, Evidence Based Birth, or other listed sources is recorded here and can be updated remotely without a new app release.
